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Ketamine therapy is for people who are suffering from treatment resistant depression, anxiety, PTSD, OCD, Bipolar Disorder, and chronic pain. Ketamine is a drug that has been FDA approved since the 1970's as an anesthetic. Since it's discovery, it has been used at sub-anesthetic doses to successfully treat mood disorders as well as chronic pain. A low dose of Ketamine is given via an intravenous route over a series of appointments that have been proven to stimulate new synapses in the brain thus creating new neural pathways. It is thought that prolonged exposure to stresses cause neurons to die off, thus causing depression but Ketamine causes those neurons to regenerate within hours, relieving those symptoms. Traditional treatment of anti-depressants work on the serotonin or norepinephrine pathways and most people say they stop working or that they don't like the side-effects these medications cause. However, Ketamine works via the glutamate pathway.
The exact mechanism of how ketamine works in treating mental health disorders is still not fully understood. However, it is believed to work by increasing the levels of glutamate, a neurotransmitter in the brain that is associated with learning, memory, and synaptic plasticity.
Ketamine is administered intravenously in a controlled setting, usually at a clinic or hospital. The dosage and duration of the treatment vary depending on the patient’s condition and response. Ketamine treatment for mental health disorders typically involves a series of sessions. The initial session can last up to two hours, during which the patient is closely monitored for any adverse effects. The subsequent sessions may be shorter and less intensive. The therapeutic effects of ketamine treatment are usually felt within hours or days after the initial session. However, the duration of the effects varies from patient to patient and may require ongoing maintenance sessions. Ketamine treatment is considered a relatively safe and effective alternative to traditional antidepressant medications, which can take weeks or months to take effect and may have adverse side effects.
Stabilization
Infusion Duration: 1 hour
Number of Treatments: 4 or 6 sessions (based on the results of your screening)
Length of Stabilization Period: Within 1-2 weeks
Infusion Duraton: 2 hour
Number of Treatments: 4 or 6 sessions (based on the results of your screening)
Length of Stabilization Period: Within 1-2 weeks
Our Ketamine treatment protocol for chronic and neuropathic pain syndromes such as Fibromyalgia and Complex Regional Pain Syndrome (CRPS). This treatment series consists of initial treatments, which are condensed into a single week.
Infusion Duration: Three hours & 45 minutes
Number of Treatments: 3 or 5 total (based on the results of your screening)
Length of Stabilization Period: Within one week
This period refers to all ongoing treatments after stabilization.
Ketamine is unique for its long-lasting benefits from just a single treatment session. Unlike most antidepressants, ketamine therapy can be scheduled on an as-needed basis. After your initial stabilization treatments, you may find that you only need maintenance treatments every 8 weeks to a few times each year.
The maintenance schedule after stabilization is two additional consecutive treatments (two weeks after stabilization), and then future treatments are based on remission and the patient’s need for additional treatments moving forward.
Study: Efficacy of ketamine therapy in the treatment of depression
Summary: “Ketamine has a robust and rapid effect on depression, which was seen immediately after the administration of ketamine and sustained at the end of 1 month.”
Study: Signaling pathways underlying the rapid antidepressant actions of ketamine
Summary: “Recent clinical studies have demonstrated that ketamine, an NMDA receptor antagonist produces a rapid antidepressant response (within hours) and is effective in treatment resistant depressed patients…Novel targets that influence glutamate transmission, BDNF-mTOR signaling, and synaptogenesis offer promise for the development of safer, rapid acting and efficacious antidepressant agents for the treatment of depression.”
Summary: “These results demonstrate that even the most treatment-resistant patients may benefit from ketamine, and that mid-to-long term treatment is effective in many patients.”
Study: https://pubmed.ncbi.nlm.nih.gov/24740528/
Summary: "Researchers analyzed eight separate studies that investigated ketamine therapy for anxiety disorders. They concluded that current research supports ketamine’s ability to provide significant relief in patients suffering from social anxiety disorder, generalized anxiety disorder, and other conditions on the anxiety spectrum. and depression."
Summary: Researchers analyzed eight separate studies that investigated ketamine therapy for anxiety disorders. They concluded that current research supports ketamine’s ability to provide significant relief in patients suffering from social anxiety disorder, generalized anxiety disorder, and other conditions on the anxiety spectrum."
Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799067/
Summary: "In 2013, a study by the American College of Neuropsychopharmacology found that ketamine can have “rapid anti-obsessional effects”in adults suffering from OCD. In this trial, ketamine treatment was specifically effective against pervasive intrusive thoughts and obsessive symptoms. The study also noted that ketamine treatment could be an important development in OCD treatment because of its fast onset compared to other medications."
Ketamine infusion therapy is research-backed, evidence-based, and has a 30-year FDA-approved safety profile. Ketamine infusions are used to successfully treat a range of anxiety disorders, including generalized anxiety disorder (GAD), social anxiety disorder (SAD), panic disorder, obsessive-compulsive disorder (OCD), and PTSD. Unlike traditional medications for anxiety, ketamine infusion therapy is typically effective within hours and symptoms can stay controlled for weeks or months between treatments.
If you are having suicidal thoughts, or you know someone who is, help is available. In the U.S., call the National Suicide Prevention Lifeline at 1-800-273-8255 or
dial 988.
Please reach us at amber@renewedvitalityandwellness.com if you cannot find an answer to your question.
COMMITMENT TO LIFE CHANGE: By the time people are seeking ketamine treatments, they have already made many accommodations in their lives for their depression, their pain, their anxiety, OCD, PTSD, etc. Some of these accommodations made can actually support their depressive symptoms. It is important to eliminate these to minimize the return of the depression and all of its symptoms. Therefore, success in maintaining the therapeutic gains can depend on changing other things in your life as well. Ketamine is not magic, very few chronic illnesses can be cured in one treatment. Commitment to the process is crucial to seeing long term results. Trying Ketamine once or twice is not going to solve all of your difficulties, make a commitment to the full series of treatments and make the lifestyle changes as well. A series of 4-6 stabilization treatments is recommended with a maintenance program of every 4-6 weeks is typically what works for most people.
Not really, it is called a dissociative drug. Dissociation can be described as transient amnesias, a twilight state, automatisms, and depersonalization. It is a distortion of perceptions of sight and sound that can produce feelings of detachment or dissociation from the environment or self. Many people feel light and like they are floating. These side effects will dissipate as soon as the infusion is complete or if the infusion is stopped for any reason. This may sound scary but most people have called this experience very pleasant and enjoyable.
It is completely up to you, this is your time. However, consider that your brain is being remodeled with new neuropathways and old neuropathways are being repaired. So essentially, what you put into your brain should be considered. During, before and after your treatments try to be positive, set intensions and continue postive affirmations. Listening to instrumental or ketamine playlists can be very positive for the mind. Blocking out all negative input is essential. You will have the option of using our noise canceling headphones and eye covers. You may listen to music that we provide or you may bring your own playlists. It is recommended that you spend some time finding what you like. There are many "ketamine therapy playlists" out there to explore. We also have access to movies, TV shows and moving art.
Typical anti-depressants take weeks to months to work. There are many of these drugs to choose from and no reliable way at this time to know which one will be effective and well-tolerated. Unfortunately, one may wait weeks and find out that they cannot tolerate it or that it doesn't work for them. These medications have many common side effects such as weight gain, sexual dysfunction, gastrointestinal disturbances, sleep disturbance, fatigue, and emotional blunting. Some newer medications that are add on antidepressants also have an increased risk for causing diabetes. You may have experienced these in the past and if you have, you probably don't want to go down that road again. Unfortunately, not everyone will respond to Ketamine, but you will know after a short time if you don't and you won't continue to waste time or go through any unpleasant side effects. Outside of the infusion time and a couple hours after, you are not "medicated".
It is very common to seek treatment for mental health that makes sense intellectually but it is impossible to follow through on because of the depressive symptoms. You may have heard "eat well, exercise, engage in talk therapy, find social support, stay busy" and so on. Ketamine rapidly enables you to be able to act on these important activities and those that have the best results support the medicine's effect in these ways. In addition, ketamine is thought to "prime" the brain for learning and making new connections. Talk therapy can be an ideal way to "lock in" therapeutic learning and capitalize on this unique window of time.
Ketamine is a medication that has been around for many decades. It can lead to the dramatic improvement in symptoms of depression, even in patients who have severe, chronic, treatment resistant mood disorders. Ketamine is FDA approved as an anesthetic agent, you may have had it before if you have had a surgery. To use it outside of this application, it is considered "off label" at this time. At sub-anesthetic doses (much lower doses than when used as an anesthetic) Ketamine may be useful in the treatment of bipolar and unipolar depression, anxiety disorders, post-traumatic stress disorders, chronic migraine, fibromyalgia, addiction and pain. Ketamine infusions work by providing medication directly into the bloodstream where it immediately begins to repair the stress-induced damage in the brain's communication system. Ketamine works on the glutamate pathways in your brain, these pathways work to communicate between neurons. When people are stressed, under pressure and have symptoms such as depression, the pathways are interrupted and functioning poorly. When Ketamine is given at low doses, these neural pathways seem to reverse and new pathways are regenerated making new neuronal connections.
Yes, our provider is serving you in a consulting capacity to provide this procedure. It is recommended that you have a mental health provider such as a psychiatrist, psychologist, therapist or counselor. It is also recommended that you have a primary care provider to get regular lab work and get regular maintenance for any health disorders. If you need help finding a mental health or primary care provider, please let us know. We would be happy to make a referral.
Uncontrolled high blood pressure, unstable heart disease, increased intracranial or intra-ocular pressure, interstitial cystitis, active substance abuse, current manic phase of bipolar disorder, and active psychotic symptoms are conditions that can be dangerous to treat with Ketamine. However, risks are minimal when these conditions are not treated. For people who do not have these conditions the dose used for the treatment of mood and anxiety disorders is very low and safe. For a short time during the infusion, blood pressure and heart rate may increase. This is monitored closely to ensure safety and medications are administered if necessary to manage problematic increases in blood pressure or episodes of nausea or anxiety.
Approximately 70-80% of patients respond to ketamine infusions. Certain genetic factors and patient characteristics may increase the likelihood of success. Factors that are associated with successful treatment include: exposure to chronic stress, family history of alcoholism, suicidal ideation, increased BMI, anxious depression, cognitive dysfunction, and a Val/Val BDNF gene.
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